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It works on wrinkles by keeping the muscles that contract to create them slack, giving a smooth appearance. Botox only lasts 4 to 6 months, so it is a rather expensive fix for something so temporary - it averages about $500 per shot. Side effects are mild when Botox is administered correctly - the most serious side effect is eyelid drooping as the medication migrates, but experts say this can be avoided by being still for a few hours after the injection and not lying down. To avoid migration and other potentially dangerous side effects, it's important to find a licensed doctor to administer Botox.