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But there's a catch. According to Mayoclinic.com, daily aspirin therapy should be considered if you have had a heart attack or stroke, or you're at high risk of either. Consult with your physician before starting an aspirin regimen. Risk factors for heart disease or stroke include smoking, high blood pressure, high total cholesterol levels of 240 or more, an LDL (bad) cholesterol level of 130 or more, lack of exercise, diabetes, stress, consuming one or more alcoholic drink a day, and a family history of stroke or heart attack. People who should not follow daily aspirin therapy include those who have a bleeding or clotting disorder, asthma, stomach ulcers, or heart failure.