Joint pain is most frequently experienced in the fingers and wrists, but is also common in the: 

• feet;
• ankles;
• knees; and
• shoulders. 

6. Stomach Irritation 

Many RA patients take nonsteroidal anti-inflammatory drugs (NSAIDs) to help treat their RA symptoms. Use of this class of drugs, which includes ibuprofen and naproxen, can increase the risk of stomach problems. Formation of stomach ulcers may occur with excessive NSAID use, which can lead to stomach bleeding or formations of holes in the stomach wall. 

Tell your doctor if you experience: 

• unusual stomach pain;
• black or bloody stools; or
• persistent nausea.