All six substitutes will allow a consumer to cut calories while enjoying treats that may be forbidden due to diabetes, hypoglycemia, and diet restrictions. All are tooth-friendly as they will not encourage dental plaque.

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With the exception of Neotame, the substitutes can be found in packets that are easy to use for sweetening cups of coffee or tea. The best sugar substitute to sweeten coffee or tea is best chosen by the individual because it's a matter of taste. The most popular substitutes in the US are sucralose (Splenda) and aspartame (NutraSweet.) The best substitute for baked goods is sucralose (Splenda) because it can be used in equal substitutions and will not alter the treat's taste.